Jesse Brown

Twitter: @jesseaaronbrown

NPI B8-169 | 310.825.9334

I'm a 5th year Ph.D. candidate in the Neuroscience IDP at UCLA.

My advisor is Dr. Susan Bookheimer.

My research is in multimodal neuroimaging of human episodic memory systems in health and neurodegeneration. Currently, I use DTI and fMRI to study connections between the hippocampus and the prefrontal cortex in normal individuals and those at greater genetic risk for developing Alzheimer's Disease. Graph theory and machine learning have become a central part of my thesis.

More generally, I'm interested in memory, early detection of neurological disease states, human brain evolution, and cognitive enhancement/augmentation.

DTI
Notes on DTI analysis including image processing, tractography, and group statistical comparisons. Also includes links to useful DTI image converters, FSL sites of interest, and papers on DTI fundamentals.

UMCD
UCLA Multimodal Connectivity Database is a site for web-based brain network analysis where researchers can share their own connectivity data and interact with other publicly shared data. It is supported by the MGH-UCLA Human Connectome Project.

Functional Connectivity
References for performing different functional connectivity analyses, including resting state analysis and PPI using FSL.

UMCP
UCLA Multimodal Connectivity Package is a set of programs I've written for calculating structural and functional connectivity metrics from diffusion weighted MRI and fMRI.

New blog
Old blog
Musings on new tools, new papers, conferences, and other miscellany.

Downloads

Jesse A. Brown, Kevin H. Terashima, Alison C. Burggren, Linda M. Ercoli, Karen J. Miller, Gary W. Small, Susan Y. Bookheimer (2011). Brain network local interconnectivity loss in aging APOE-4 allele carriers. Proc Natl Acad Sci. 10.1073/pnas.1109038108 PDF

Emily L. Dennis, Neda Jahanshad, Jeffrey D. Rudie, Jesse A. Brown, Kori Johnson, Katie L. McMahon, Greig I. de Zubicaray, Grant Montgomery, Nicholas G. Martin, Margaret J. Wright, Susan Y. Bookheimer, Mirella Dapretto, Arthur W. Toga, Paul M. Thompson. Abnormal Structural Brain Connectivity in Healthy Carriers of the Autism Risk Gene, CNTNAP2. Brain Connectivity, 2012 Feb 29. [Epub ahead of print]. doi:10.1089/brain.2011.0064 PDF

Danielle S. Bassett, Jesse A. Brown, Vibhas Deshpande, Jean M. Carlson, Scott T. Grafton. Conserved and variable architecture of human white matter connectivity. Neuroimage 54(2):1262-79 (2011). 10.1016/j.neuroimage.2010.09.006

Natcha Opalka, Jesse Brown, William J. Lane, Kelly-Anne F. Twist, Robert Landick, Francisco J. Asturias, Seth A. Darst. Complete Structural Model of Escherichia coli RNA Polymerase from a Hybrid Approach. PLoS Biology 8(9): e1000483 (2010). 10.1371/journal.pbio.1000483

Yuchiro Takagi, Guillermo Calero, Hirofumi Komori, Jesse A. Brown, Andres Ehrensberger, Andy Hudmon, Francisco J. Asturias, Roger D. Kornberg. Head Module Control of Mediator Interactions. Molecular Cell 23:355-364 (2006). 10.1016/j.molcel.2006.06.007

My CV.